Short reportImprovement in erectile function following weight loss in obese men: The SHED-IT randomized controlled trial
Section snippets
Trial registration
Australian New Zealand Clinical Trials Registry (ACTRN12610000699066).
Funding source
Heart Foundation of Australia.
Conflict of interest
There are no conflicts of interest, financial or otherwise, of any of the authors.
Acknowledgements
The SHED-IT RCT is funded by a National Heart Foundation Grant-in-Aid (2010-2011). The funding bodies did not have any input into the design of the study, the collection or analysis of data, the preparation of this manuscript, or the decision to submit this manuscript for publication. We would like to thank the participating men. We would also like to thank James Dower, Bryana Melnik, Dana Williams, Alyce Cook, Trish Robson, Bronwyn Berthon, Ashlee Lucas, Roberta Asher, Sarah Costigan, Peter
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Cited by (20)
Obesity and male infertility
2023, Best Practice and Research: Clinical Obstetrics and GynaecologyObesity and reproduction: a committee opinion
2021, Fertility and SterilityCitation Excerpt :A diagnosis of male infertility may provide a unique opportunity to motivate men with obesity to lose weight. Weight loss results in increased testosterone levels (170, 171) and improvements in sexual function (172, 173). A prospective study assessing shorter- and longer-term impacts of diet-induced weight loss in 118 overweight (N = 32) and obese (N = 86) men tracked testosterone and self-reported sexual function, as reported by the International Index of Erectile Function (IIEF), during a 12-week weight loss period, followed by 40 weeks of maintenance (171).
Vasculogenic Erectile Dysfunction: The Impact of Diet and Lifestyle
2021, American Journal of MedicineCitation Excerpt :Overall, the intervention group lost significantly more weight and had a significantly increased mean International Index of Erectile Function-5 score compared with control subjects. In subjects with erectile dysfunction at baseline, the intervention group experienced a greater and significant increase in International Index of Erectile Function-5 score, of 4.2 points, versus control.20 In summary, although these studies were relatively small and of short duration and did not control for all potential confounders (eg, changes in psychological measures), each suggests that achieving weight loss through caloric reduction and increased energy expenditure can be recommended to men with obesity as a means of improving erectile function.
Dietary Modification Is Associated with Normalization of Penile Hemodynamics in Rats Fed a High-Fat Diet
2019, Journal of Sexual MedicineCitation Excerpt :The beneficial effects of weight loss (≥10%) were demonstrated in a randomized, single-blinded trial of 110 obese men age 35–55 years with ED without diabetes, hypertension, or hyperlipidemia, in which the mean IIEF score improved in the intervention group (from 13.9 ± 4.0 to 17 ± 5; P < .001), but remained stable in the control group.20 Weight loss in obese men has been related to improved ED.21 However, consistent maintenance of weight at an ideal level may be complicated by poor patient compliance.
The 2018 Revision to the Process of Care Model for Management of Erectile Dysfunction
2018, Journal of Sexual MedicineCitation Excerpt :2 randomized studies of men with ED demonstrated that the addition of a prespecified exercise program to PDE5I treatment was associated with improvements in erectile function compared with controls.26,27 Weight loss, which should follow increased physical activity and improved diet, is associated with improvement in erectile function among obese men with ED, with or without comorbidities.28–30 However, data from the Massachusetts Male Aging Study suggest that the benefits of weight loss may be much more evident before middle age.31
Obesity and Reproduction
2018, Journal of Obstetrics and Gynaecology CanadaCitation Excerpt :In contrast the literature clearly shows that obese men have a higher incidence of erectile dysfunction.29,64,65 Several randomized controlled trials have demonstrated that lifestyle changes associated with weight loss may improve erectile dysfunction in obese men.66,67 Similarly, improvement in erectile function have been documented after bariatric surgery.68–72