Obesity Research & Clinical Practice
Volume 6, Issue 1 , Pages e1-e8, January 2012

Association between insulin resistance, cardiovascular risk factors and overweight in Japanese schoolchildren

  • Chie Fujii

      Affiliations

    • Department of School Health Sciences, Aichi University of Education, 1 Hirosawa, Igaya-cho, Kariya, Aichi 448-8542, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 566 26 2499; fax: +81 566 26 2499.
    • ,
  • Hisataka Sakakibara

      Affiliations

    • Department of Public Health and Community Nursing, Nagoya University School of Health Sciences, Aichi, Japan

Received 9 February 2011; received in revised form 8 April 2011; accepted 12 April 2011. published online 19 May 2011.

Summary 

Objective

The aim of this study was to examine the association between insulin resistance, cardiovascular risk factors and overweight in Japanese schoolchildren.

Methods

A cross-sectional study was performed on 310 schoolchildren (155 boys and 155 girls) of the fifth grade and the eighth grade in a town in Nagano Prefecture, Japan. The survey was conducted on anthropometric, blood examinations, and by calculation of body mass index (BMI: body weight/body height2) and HOMA-IR (fasting insulin×fasting glucose/405).

Results

Hemoglobin A1c and fasting glucose were not associated with BMI, whereas fasting insulin and HOMA-IR were significantly higher in overweight children in comparison with the lowest quartile BMI group. In the overweight, the mean and standard deviation of HOMA-IR were 2.51±1.01, and the prevalence of HOMA-IR≧2.5 was 46.8%. Schoolchildren with HOMA-IR≧2.5 had more several cardiovascular risk factors.

Conclusions

Insulin resistance was observed in overweight Japanese children, though their hemoglobin A1c and fasting glucose were within the normal range. In addition, with higher BMI, the number of cardiovascular risk factors was increased. Weight management should be started in childhood.

Keywords: Insulin resistance, Cardiovascular risk factors, Overweight, Schoolchildren

 

PII: S1871-403X(11)00022-6

doi:10.1016/j.orcp.2011.04.002

Obesity Research & Clinical Practice
Volume 6, Issue 1 , Pages e1-e8, January 2012

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