Obesity Research & Clinical Practice
Volume 4, Issue 4 , Pages e261-e269 , October 2010

Prevalence and risk factors for gastroesophageal reflux disease in an impoverished minority population

  • Frank K. Friedenberg

      Affiliations

    • Temple University School of Medicine, Philadelphia, PA, United States
    • Corresponding Author InformationCorresponding author at: Gastroenterology Section – 8PP, Temple University Hospital, 3401 N. Broad Street, Philadelphia, PA 19140, United States. Tel.: +1 215 707 4391; fax: +1 215 707 2684.
  • ,
  • Jitha Rai

      Affiliations

    • Temple University School of Medicine, Philadelphia, PA, United States
  • ,
  • Vishwas Vanar

      Affiliations

    • Temple University School of Medicine, Philadelphia, PA, United States
  • ,
  • Charles Bongiorno

      Affiliations

    • Temple University School of Medicine, Philadelphia, PA, United States
  • ,
  • Deborah B. Nelson

      Affiliations

    • The Graduate School of Public Health, Temple University, Philadelphia, PA, United States
  • ,
  • Mayur Parepally

      Affiliations

    • Temple University School of Medicine, Philadelphia, PA, United States
  • ,
  • Arashdeep Poonia

      Affiliations

    • Temple University School of Medicine, Philadelphia, PA, United States
  • ,
  • Amol Sharma

      Affiliations

    • Temple University School of Medicine, Philadelphia, PA, United States
  • ,
  • Shaun Gohel

      Affiliations

    • Temple University School of Medicine, Philadelphia, PA, United States
  • ,
  • Joel E. Richter

      Affiliations

    • Temple University School of Medicine, Philadelphia, PA, United States

Received 23 April 2010 ,Revised 28 June 2010 ,Accepted 28 June 2010.

References 

  1. Kuczmarski RJ, Flegal KM, Campbell SM, Johnson CL. Increasing prevalence of overweight among US adults. The National Health and Nutrition Examination Surveys, 1960 to 1991. JAMA. 1994;272:205–211
  2. Crowell MD, Bradley A, Hansel S, Dionisio P, Kim HJ, Decker GA, et al. Obesity is associated with increased 48-h esophageal acid exposure in patients with symptomatic gastroesophageal reflux. Am J Gastroenterol. 2009;104:553–559
  3. El-Serag HB, Graham DY, Satia JA, Rabeneck L. Obesity is an independent risk factor for GERD symptoms and erosive esophagitis. Am J Gastroenterol. 2005;100:1243–1250
  4. Jacobson BC, Somers SC, Fuchs CS, Kelly CP, Camargo CA. Body-mass index and symptoms of gastroesophageal reflux in women. N Engl J Med. 2006;354:2340–2348
  5. Kouklakis G, Moschos J, Kountouras J, Mpoumponaris A, Molyvas E, Minopoulos G. Relationship between obesity and gastroesophageal reflux disease as recorded by 3-hour esophageal pH monitoring. Rom J Gastroenterol. 2005;14:117–121
  6. Goh KL. Obesity and increasing gastroesophageal reflux disease in Asia. J Gastroenterol Hepatol. 2007;22:1557–1558
  7. Kang MS, Park DI, Oh SY, Yoo TW, Ryu SH, Park JH, et al. Abdominal obesity is an independent risk factor for erosive esophagitis in a Korean population. J Gastroenterol Hepatol. 2007;22:1656–1661
  8. Edelstein ZR, Farrow DC, Bronner MP, Rosen SN, Vaughan TL. Central adiposity and risk of Barrett's esophagus. Gastroenterology. 2007;133:403–411
  9. El-Serag HB, Kvapil P, Hacken-Bitar J, Kramer JR. Abdominal obesity and the risk of Barrett's esophagus. Am J Gastroenterol. 2005;100:2151–2156
  10. Abrams JA, Fields S, Lightdale CJ, Neugut AI. Racial and ethnic disparities in the prevalence of Barrett's esophagus among patients who undergo upper endoscopy. Clin Gastroenterol Hepatol. 2008;6:30–34
  11. Spechler SJ, Jain SK, Tendler DA, Parker RA. Racial differences in the frequency of symptoms and complications of gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 2002;16:1795–1800
  12. Corley DA, Kubo A, Zhao W. Abdominal obesity, ethnicity and gastro-oesophageal reflux symptoms. Gut. 2007;56:756–762
  13. Friedenberg FK, Hanlon A, Vanar V, Nehemia D, Mekapati J, Nelson DB, et al. Trends in gastroesophageal reflux disease as measured by the National Ambulatory Medical Care Survey. Dig Dis Sci. 2009;
  14. Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R Global Consensus Group. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol. 2006;101:1900–1920quiz 1943
  15. Ervin RB. Prevalence of metabolic syndrome among adults 20 years of age and over, by sex, age, race and ethnicity, and body mass index: United States, 2003–2006. Natl Health Stat Rep. 2009;13:1–7
  16. Everhart JE, Ruhl CE. Burden of digestive diseases in the United States part I: overall and upper gastrointestinal diseases. Gastroenterology. 2009;136:376–386
  17. Brook RD, Bard RL, Rubenfire M, Ridker PM, Rajagopalan S. Usefulness of visceral obesity (waist/hip ratio) in predicting vascular endothelial function in healthy overweight adults. Am J Cardiol. 2001;88:1264–1269
  18. Rey E, Moreno-Elola-Olaso C, Artalejo FR, Locke GR, Diaz-Rubio M. Association between weight gain and symptoms of gastroesophageal reflux in the general population. Am J Gastroenterol. 2006;101:229–233
  19. El-Serag HB, Ergun GA, Pandolfino J, Fitzgerald S, Tran T, Kramer JR. Obesity increases oesophageal acid exposure. Gut. 2007;56:749–755
  20. Corley DA, Kubo A, Levin TR, Block G, Habel L, Zhao W, et al. Abdominal obesity and body mass index as risk factors for Barrett's esophagus. Gastroenterology. 2007;133:34–41quiz 311
  21. Lambert DM, Marceau S, Forse RA. Intra-abdominal pressure in the morbidly obese. Obes Surg. 2005;15:1225–1232
  22. Varela JE, Hinojosa M, Nguyen N. Correlations between intra-abdominal pressure and obesity-related co-morbidities. Surg Obes Relat Dis. 2009;
  23. El-Serag HB, Tran T, Richardson P, Ergun G. Anthropometric correlates of intragastric pressure. Scand J Gastroenterol. 2006;41:887–891
  24. Pandolfino JE, El-Serag HB, Zhang Q, Shah N, Ghosh SK, Kahrilas PJ. Obesity: a challenge to esophagogastric junction integrity. Gastroenterology. 2006;130:639–649
  25. Gallagher TK, Geoghegan JG, Baird AW, Winter DC. Implications of altered gastrointestinal motility in obesity. Obes Surg. 2007;17:1399–1407
  26. Hirsch DP, Mathus-Vliegen EM, Holloway RH, Fakhry N, D’Amato M, Boeckxstaens GE. Role of CCK(A) receptors in postprandial lower esophageal sphincter function in morbidly obese subjects. Dig Dis Sci. 2002;47:2531–2537
  27. Hong D, Khajanchee YS, Pereira N, Lockhart B, Patterson EJ, Swanstrom LL. Manometric abnormalities and gastroesophageal reflux disease in the morbidly obese. Obes Surg. 2004;14:744–749
  28. Iovino P, Angrisani L, Galloro G, Consalvo D, Tremolaterra F, Pascariello A, et al. Proximal stomach function in obesity with normal or abnormal oesophageal acid exposure. Neurogastroenterol Motil. 2006;18:425–432
  29. Kahrilas PJ, Shi G, Manka M, Joehl RJ. Increased frequency of transient lower esophageal sphincter relaxation induced by gastric distention in reflux patients with hiatal hernia. Gastroenterology. 2000;118:688–695
  30. Koppman JS, Poggi L, Szomstein S, Ukleja A, Botoman A, Rosenthal R. Esophageal motility disorders in the morbidly obese population. Surg Endosc. 2007;21:761–764
  31. Maddox A, Horowitz M, Wishart J, Collins P. Gastric and oesophageal emptying in obesity. Scand J Gastroenterol. 1989;24:593–598
  32. Mathus-Vliegen EM, van Weeren M, van Eerten PV. Los function and obesity: the impact of untreated obesity, weight loss, and chronic gastric balloon distension. Digestion. 2003;68:161–168
  33. Merrouche M, Sabaté JM, Jouet P, Harnois F, Scaringi S, Coffin B, et al. Gastro-esophageal reflux and esophageal motility disorders in morbidly obese patients before and after bariatric surgery. Obes Surg. 2007;17:894–900
  34. Schneider JH, Kuper M, Konigsrainer A, Brucher B. Transient lower esophageal sphincter relaxation in morbid obesity. Obes Surg. 2009;19:595–600
  35. Tosetti C, Corinaldesi R, Stanghellini V, Pasquali R, Corbelli C, Zoccoli G, et al. Gastric emptying of solids in morbid obesity. Int J Obes Relat Metab Disord. 1996;20:200–205
  36. Wright RA, Krinsky S, Fleeman C, Trujillo J, Teague E. Gastric emptying and obesity. Gastroenterology. 1983;84:747–751
  37. Wu JC, Mui LM, Cheung CM, Chan Y, Sung JJ. Obesity is associated with increased transient lower esophageal sphincter relaxation. Gastroenterology. 2007;132:883–889
  38. Zahorska-Markiewicz B, Jonderko K, Lelek A, Skrzypek D. Gastric emptying in obesity. Hum Nutr Clin Nutr. 1986;40:309–313
  39. Canoz M, Erdenen F, Uzun H, Muderrisoglu C, Aydin S. The relationship of inflammatory cytokines with asthma and obesity. Clin Invest Med. 2008;31:E373–E379
  40. Nilsson M, Johnsen R, Ye W, Hveem K, Lagergren J. Lifestyle related risk factors in the aetiology of gastro-oesophageal reflux. Gut. 2004;53:1730–1735
  41. Watanabe Y, Fujiwara Y, Shiba M, Watanabe T, Tominaga K, Oshitani N, et al. Cigarette smoking and alcohol consumption associated with gastro-oesophageal reflux disease in Japanese men. Scand J Gastroenterol. 2003;38:807–811
  42. Kahrilas PJ, Gupta RR. Mechanisms of acid reflux associated with cigarette smoking. Gut. 1990;31:4–10

PII: S1871-403X(10)00015-3

doi: 10.1016/j.orcp.2010.06.001

Obesity Research & Clinical Practice
Volume 4, Issue 4 , Pages e261-e269 , October 2010